job_120512a: Product Development Engineer, myoscience (Redwood City, CA)

From: Kristin Burns <kristin.burns_at_stanford.edu>
Date: Wed, 05 Dec 2012 06:41:11 -0800

Introduction to myoscience

myoscience Inc., located in Redwood City, CA, has
developed a revolutionary medical device that
provides a natural alternative for treating
dynamic facial wrinkles. The treatment offers
immediate efficacy, superior outcomes, an
excellent safety profile, and achieves these
results using only the body’s natural physiology, leaving nothing behind.

The only treatment currently available for
treating dynamic wrinkles is botulinum toxin,
which is available as Botox®, Dysport®, Xeomin®,
and other formulations. All toxins have a “Black
Box” warning in the US and have been plagued with
safety concerns around the potency of the poison,
migration, and development of antibodies. The
myoscience treatment will appeal to the
aesthetically-oriented individual who does not
want to inject a toxin, but does want to
naturally eliminate wrinkles. In doing so,
myoscience has an opportunity to significantly
expand the ~$900M WW market that toxins have defined.

The Company has demonstrated and reproduced
safety and efficacy results in trials
involving >500 subjects in the US and Europe.
Current trials are using a commercial-ready
device, but earlier generations have already
received (3) 510K clearances for non-cosmetic
indications. The Company has begun commercial
operations in Europe, scaling up a robust OUS
business while preparing for a US launch in
2013/14. At scale, myoscience will deliver gross
margins in excess of 90%. The management has
extensive experience and a strong track record in
product development, clinical development,
product launch, and commercial operations.

Market Opportunity

Dynamic facial wrinkles are caused by the
repetitive contraction of facial muscles. The
demand for neurotoxins has exceeded anyone’s
original expectations with current sales of ~875M
WW, ~$400M in the US and continued strong growth
despite the recent economic downturn. In the US,
that robust market has been built on just 1.2M
consumers. By Allergan’s own accounts, twice that
number may be waiting in the wings for a
non-toxin alternative. These are patients who are
reluctant to inject a poison that has a “Black
Box” warning from the FDA. Until now, those consumers had no options.

myoscience alone is targeting those 2.4M women
and men (and more outside the US) who are not
captured by the multiple toxin manufacturers. By
capturing patients already in the physicians’
office and growing from there, myoscience can
easily scale to a $300M global revenue run rate
within 5 years in the base case, with
significantly greater upside potential. Clinical
testing is underway for additional cosmetic and
non-cosmetic indications that would multiply myoscience’s addressable market.

myoscience Treatment

The myoscience device is a fully contained system
that denervates a target area by delivering short
bursts of precisely controlled cooling to a
specific nerve. The device consists of a base
station and reusable handpiece. The handpiece
uses disposable refrigerant cartridges and small
needles called cryoprobes. After the cryoprobes
are inserted into the skin, the tip of the needle
cools down to -60°C creating a zone of cold
tissue surrounding the tip. As the cold zone
grows to involve the nerve, nerve conduction is
interrupted followed by “cryo-denervation.” With
the motor nerve denervated, the muscle it
activates can no longer contract and the facial
muscles gently relax without the use of drugs or
other material left behind in the body. As
established in prior literature over the last 40
years and supported by the Company’s preclinical
and clinical data, cold treatment to induce a
functional extended nerve block is extremely safe
with full and reliable recovery of structure and function.

Position

myoscience development environment - we’re a
small team of experienced professionals working
with technology and business decisions in a fast
paced, high quality workplace. You should be
comfortable understanding requirements,
schedules, and risks and how to deploy iterative,
evolving platforms and systems. We value
collaboration and respect and take pride in our ability to deliver.

Product Development Engineer: BSME; systems
development, requirements decomposition, and
design practices compliant with quality and
design control systems appropriate for class II medical devices:
    * Design of consumable components for low cost and high volume production
    * Design test equipment and fixturing; build
prototype devices; write test protocols, conduct tests and complete reports
    * Design mechanical/electrical assemblies,
complete drawing packages, and develop work instructions for assembly
    * Facilitate standards and qualifications
testing such as IEC60601 safety, environmental, and emissions
    * Design transfer to contract manufacturer
    * Ability to efficiently own and execute on multiple concurrent projects
    * Proficient with Microsoft Word, Excel, and PowerPoint
    * Knowledge and experience with plastic
injection molding, metals, machining, plating, joining techniques
    * Knowledge and experience in two or more of the following areas:
        * Fluid dynamics
        * High pressure interfaces
        * Heat transfer / Thermodynamics
        * Metals material science
        * Needle design and manufacture
    * Experience designing products using
SolidWorks (advanced surfacing, sheet metal,
collaboration techniques) and related PDM systems
    * Proven track record using a variety of
design tools and prototyping techniques to
develop and transfer to production successful
products that pass worldwide compliance requirements
    * Strong analytical and communication skills (written and verbal)
If your experience and skills meet or exceed our
needs, please e-mail your resume to:
<mailto:pgovenji_at_myoscience.com>pgovenji_at_myoscience.com.
Please also include a portfolio showing some of
your work. Your portfolio can include CAD and engineering analysis.

- - - - - - - - - - - - - - - - - - -
Potential applicants should communicate directly
with the contact listed in the posting. Please
do not "reply" to the posting messages.

Job postings are archived at http://design.stanford.edu/archive/

Note: The job postings distribution list
contains several distribution lists: Design grad
students, ME310 alumni, ME218 alumni, ME jobs
list, etc. Members of multiple lists will
receive multiple copies of postings. Please
excuse the duplication. Thank you.
Received on 2012-12-05 06:41:07

This archive was generated by hypermail 2.3.0 : 2016-01-25 19:18:18 PST